MyBioSource.com's IKBKE Mouse mAb is a Mouse monoclonal antibody. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degra-dation of IkappaB. IkappaB kinase alpha(IKKalpha), previously designated CHUK, interacts with IkappaB-alphaand specifically phosphorylates IkappaB-alphaon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKalpha, IKKbetaand IKKgamma(also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKalphaand IKKbeta. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFalpha, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IkappaBalphaon Ser32 andSer36, and in NFkappaB activation, suggesting that IKK-i may act as an IkappaB kinase in the immune system